Clopidogrel e Omeprazol
A interação medicamentosa é um dos assuntos mais correntes e mais esquecidos pelos médicos e demais profissionais de saúde. Baseado no conceito de "less is more" os prescrições tanto hospitalares como ambulatoriais devem seguir indicações muito precisas.
O uso de inibidores de bomba de prótons (omeprazol, pantoprazol, rabeprazol, nexium) é comum nas prescrições de vários médicos, principalmente cardiologistas e ortopedistas, eles vinculam o uso de AAS, Clopidogrel, ou AINEs a prescição dessas dogras.
Esse alesta do FDA define que o uso concomitante de clopidogrel e omeprazol reduz a eficiência do clopidogrel.
CLOPIDOGREL (MARKETED AS PLAVIX) AND OMEPRAZOLE (MARKETED AS PRILOSEC) - DRUG INTERACTION
FDA notified healthcare professionals of new safety information concerning an interaction between clopidogrel (Plavix), an anti-clotting medication, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid. New data show that when clopidogrel and omeprazole are taken together, the effectiveness of clopidogrel is reduced. Patients at risk for heart attacks or strokes who use clopidogrel to prevent blood clots will not get the full effect of this medicine if they are also taking omeprazole. Separating the dose of clopidogrel and omeprazole in time will not reduce this drug interaction.
Other drugs that are expected to have a similar effect and should be avoided in combination with clopidogrel include: cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine, and ticlopidine.
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